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The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1α signaling
Aberrant cell surface glycosylation is prevalent in tumor cells, and there is ample evidence that glycans have functional roles in carcinogenesis. Nonetheless, many molecular details remain unclear. Tumor cells frequently exhibit increased α2–6 sialylation on N-glycans, a modification that is added...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5900773/ https://ncbi.nlm.nih.gov/pubmed/29475939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001194 |
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