Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells

Abstract Background The ST6Gal-I glycosyltransferase, which adds α2–6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer. Prior studies have shown that ST6Gal-I-mediated sialylation of select surface receptors remodels intracellular...

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Main Authors: Kaitlyn A. Dorsett, Robert B. Jones, Katherine E. Ankenbauer, Anita B. Hjelmeland, Susan L. Bellis
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-10-01
Colecção:Journal of Ovarian Research
Assuntos:
Sialic acid
ST6Gal-I
Sox2
3q26 amplicon
Cancer stem cells
Ovarian cancer
Acesso em linha:http://link.springer.com/article/10.1186/s13048-019-0574-5
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