Estrogens Counteract Platinum-Chemosensitivity by Modifying the Subcellular Localization of MDM4

Estrogen activity towards cancer-related pathways can impact therapeutic intervention. Recent omics data suggest possible crosstalk between estrogens/gender and MDM4, a key regulator of p53. Since MDM4 can either promote cell transformation or enhance DNA damage-sensitivity, we analysed in vivo impa...

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Gepubliceerd in:Cancers (Basel)
Hoofdauteurs: Lucà, Rossella, di Blasio, Giorgia, Gallo, Daniela, Monteleone, Valentina, Manni, Isabella, Fici, Laura, Buttarelli, Marianna, Ciolli, Germana, Pellegrino, Marsha, Teveroni, Emanuela, Maiullari, Silvia, Ciucci, Alessandra, Apollo, Alessandro, Mancini, Francesca, Gentileschi, Maria Pia, Zannoni, Gian Franco, Pontecorvi, Alfredo, Scambia, Giovanni, Moretti, Fabiola
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6770881/
https://ncbi.nlm.nih.gov/pubmed/31547268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11091349
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