MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability

BACKGROUND: Many tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor with oncogenic or anti-survival activities depending on cell growth conditions....

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Dettagli Bibliografici
Pubblicato in:Mol Cancer
Autori principali: Mancini, Francesca, Teveroni, Emanuela, Di Conza, Giusy, Monteleone, Valentina, Arisi, Ivan, Pellegrino, Marsha, Buttarelli, Marianna, Pieroni, Luisa, D’Onofrio, Mara, Urbani, Andrea, Pontecorvi, Alfredo, Mazzone, Massimiliano, Moretti, Fabiola
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341177/
https://ncbi.nlm.nih.gov/pubmed/28270148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0626-7
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