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Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity

Derivatives of tirapazamine and other heteroaromatic N-oxides (ArN→O) exhibit promising antibacterial, antiprotozoal, and tumoricidal activities. Their action is typically attributed to bioreductive activation and free radical generation. In this work, we aimed to clarify the mechanism(s) of aerobic...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Nemeikaitė-Čėnienė, Aušra, Šarlauskas, Jonas, Jonušienė, Violeta, Marozienė, Audronė, Misevičienė, Lina, Yantsevich, Aliaksei V., Čėnas, Narimantas
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769651/
https://ncbi.nlm.nih.gov/pubmed/31533349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20184602
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