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Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase

With the aim to clarify the mechanism(s) of action of nitroaromatic compounds against the malaria parasite Plasmodium falciparum, we examined the single-electron reduction by P. falciparum ferredoxin:NADP(+) oxidoreductase (PfFNR) of a series of nitrofurans and nitrobenzenes (n = 23), and their abil...

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Библиографические подробности
Опубликовано в: :Molecules
Главные авторы: Marozienė, Audronė, Lesanavičius, Mindaugas, Davioud-Charvet, Elisabeth, Aliverti, Alessandro, Grellier, Philippe, Šarlauskas, Jonas, Čėnas, Narimantas
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2019
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943496/
https://ncbi.nlm.nih.gov/pubmed/31835450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244509
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