Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase

With the aim to clarify the mechanism(s) of action of nitroaromatic compounds against the malaria parasite Plasmodium falciparum, we examined the single-electron reduction by P. falciparum ferredoxin:NADP(+) oxidoreductase (PfFNR) of a series of nitrofurans and nitrobenzenes (n = 23), and their abil...

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Detaylı Bibliyografya
Yayımlandı:Molecules
Asıl Yazarlar: Marozienė, Audronė, Lesanavičius, Mindaugas, Davioud-Charvet, Elisabeth, Aliverti, Alessandro, Grellier, Philippe, Šarlauskas, Jonas, Čėnas, Narimantas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943496/
https://ncbi.nlm.nih.gov/pubmed/31835450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244509
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