Polyisoprenylated cysteinyl amide inhibitors deplete K-Ras and induce caspase-dependent apoptosis in lung cancer cells

BACKGROUND: Non-small cell lung cancers (NSCLC) harboring mutation-induced dysregulation of Ras signaling present some of the most difficult-to-manage cases since directly targeting the constitutively active mutant Ras proteins has not resulted in clinically useful drugs. Therefore, modulating Ras a...

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Detalhes bibliográficos
Publicado no:Curr Cancer Drug Targets
Main Authors: Nkembo, Augustine T., Amissah, Felix, Ntantie, Elizabeth, Poku, Rosemary A., Salako, Olufisayo O., Ikpatt, Offiong Francis, Lamango, Nazarius S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768771/
https://ncbi.nlm.nih.gov/pubmed/30914025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1568009619666190325144636
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