Polyisoprenylated cysteinyl amide inhibitors deplete K-Ras and induce caspase-dependent apoptosis in lung cancer cells

BACKGROUND: Non-small cell lung cancers (NSCLC) harboring mutation-induced dysregulation of Ras signaling present some of the most difficult-to-manage cases since directly targeting the constitutively active mutant Ras proteins has not resulted in clinically useful drugs. Therefore, modulating Ras a...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Curr Cancer Drug Targets
Hoofdauteurs: Nkembo, Augustine T., Amissah, Felix, Ntantie, Elizabeth, Poku, Rosemary A., Salako, Olufisayo O., Ikpatt, Offiong Francis, Lamango, Nazarius S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768771/
https://ncbi.nlm.nih.gov/pubmed/30914025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1568009619666190325144636
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items