Suppression of focal adhesion formation may account for the suppression of cell migration, invasion and growth of non-small cell lung cancer cells following treatment with polyisoprenylated cysteinyl amide inhibitors

Migratory cells form extracellular matrix attachments called focal-adhesions. Focal adhesion assembly and disassembly are regulated by the Rho family of small GTPases. We previously reported that polyisoprenylated cysteinyl amide inhibitors (PCAIs) suppress Rho protein levels, disrupting F-actin cyt...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ntantie, Elizabeth, Allen, Michaela J., Fletcher, Jerrine, Nkembo, Augustine T., Lamango, Nazarius S., Ikpatt, Offiong F.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995249/
https://ncbi.nlm.nih.gov/pubmed/29899821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25372
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