Suppression of focal adhesion formation may account for the suppression of cell migration, invasion and growth of non-small cell lung cancer cells following treatment with polyisoprenylated cysteinyl amide inhibitors

Migratory cells form extracellular matrix attachments called focal-adhesions. Focal adhesion assembly and disassembly are regulated by the Rho family of small GTPases. We previously reported that polyisoprenylated cysteinyl amide inhibitors (PCAIs) suppress Rho protein levels, disrupting F-actin cyt...

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Vydáno v:Oncotarget
Hlavní autoři: Ntantie, Elizabeth, Allen, Michaela J., Fletcher, Jerrine, Nkembo, Augustine T., Lamango, Nazarius S., Ikpatt, Offiong F.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995249/
https://ncbi.nlm.nih.gov/pubmed/29899821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25372
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