Inhibition of integrin α(D)β(2)–mediated macrophage adhesion to end product of docosahexaenoic acid (DHA) oxidation prevents macrophage accumulation during inflammation

A critical step in the development of chronic inflammatory diseases is the accumulation of proinflammatory macrophages in the extracellular matrix (ECM) of peripheral tissues. The adhesion receptor integrin α(D)β(2) promotes the development of atherosclerosis and diabetes by supporting macrophage re...

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Publicado en:J Biol Chem
Autores principales: Cui, Kui, Podolnikova, Nataly P., Bailey, William, Szmuc, Eric, Podrez, Eugene A., Byzova, Tatiana V., Yakubenko, Valentin P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768641/
https://ncbi.nlm.nih.gov/pubmed/31395659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009590
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