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Role of the active zone protein, ELKS, in insulin secretion from pancreatic β-cells

BACKGROUND: Insulin is stored within large dense-core granules in pancreatic beta (β)-cells and is released by Ca(2+)-triggered exocytosis with increasing blood glucose levels. Polarized and targeted secretion of insulin from β-cells in pancreatic islets into the vasculature has been proposed; howev...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Ohara-Imaizumi, Mica, Aoyagi, Kyota, Ohtsuka, Toshihisa
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768504/
https://ncbi.nlm.nih.gov/pubmed/31500835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.06.017
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