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Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes
BACKGROUND: Myriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) — a condition referred to as “ER stress” — activate intracellular signaling pathways termed the unfolded protein response (UPR). SCOPE OF REVIEW: Throu...
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| Publicado no: | Mol Metab |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6768499/ https://ncbi.nlm.nih.gov/pubmed/31500832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.06.012 |
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