Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS

Vandetanib (Caprelsa tablets, VNT) is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the characterization and identification of in vitro, in vivo and reactive intermediates of VNT. In vitro metabolites of VNT were performed by incubation with rat l...

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Bibliographische Detailangaben
Veröffentlicht in:Chem Cent J
Hauptverfasser: Attwa, Mohamed W., Kadi, Adnan A., Darwish, Hany W., Amer, Sawsan M., Al-shakliah, Nasser S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6768145/
https://ncbi.nlm.nih.gov/pubmed/30251155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13065-018-0467-5
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