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Ligand-directed serotonin 5-HT(2C) receptor desensitization and sensitization
Exposure of G protein–coupled receptors (GPCRs) to agonists can desensitize receptor signaling and lead to drug tolerance, whereas inverse agonists can sensitize signaling. For example, activation of serotonin 5-HT(2C) GPCRs is pharmacotherapeutic for obesity, but there is tolerance to the anorectic...
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| Izdano u: | Eur J Pharmacol |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6767919/ https://ncbi.nlm.nih.gov/pubmed/30689993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2019.01.037 |
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