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Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases
Enzymes with a protein kinase fold transfer phosphate from ATP to substrates in a process known as phosphorylation. Here we show that the Legionella meta-effector SidJ adopts a protein kinase fold, yet unexpectedly catalyzes protein polyglutamylation. SidJ is activated by host cell calmodulin to pol...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6767918/ https://ncbi.nlm.nih.gov/pubmed/31123136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw7446 |
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