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Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases
Enzymes with a protein kinase fold transfer phosphate from ATP to substrates in a process known as phosphorylation. Here we show that the Legionella meta-effector SidJ adopts a protein kinase fold, yet unexpectedly catalyzes protein polyglutamylation. SidJ is activated by host cell calmodulin to pol...
Shranjeno v:
| izdano v: | Science |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6767918/ https://ncbi.nlm.nih.gov/pubmed/31123136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaw7446 |
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