Protein AMPylation by an evolutionarily conserved pseudokinase

Approximately 10% of human protein kinases are believed to be inactive and named pseudokinases because they lack residues required for catalysis. Here we show that the highly conserved pseudokinase selenoprotein-O (SelO) transfers AMP from ATP to Ser, Thr and Tyr residues on protein substrates (AMPy...

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Publicado no:Cell
Main Authors: Sreelatha, Anju, Yee, Samantha S., Lopez, Victor A., Park, Brenden C., Kinch, Lisa, Pilch, Sylwia, Servage, Kelly A., Zhang, Junmei, Jiou, Jenny, Karasiewicz, Monika, Łobocka, Małgorzata, Grishin, Nick, Orth, Kim, Kucharczyk, Roza, Pawłowski, Krzysztof, Tomchick, Diana R., Tagliabracci, Vincent S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524645/
https://ncbi.nlm.nih.gov/pubmed/30270044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.046
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