Protein AMPylation by an evolutionarily conserved pseudokinase

Approximately 10% of human protein kinases are believed to be inactive and named pseudokinases because they lack residues required for catalysis. Here we show that the highly conserved pseudokinase selenoprotein-O (SelO) transfers AMP from ATP to Ser, Thr and Tyr residues on protein substrates (AMPy...

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Bibliographic Details
Published in:Cell
Main Authors: Sreelatha, Anju, Yee, Samantha S., Lopez, Victor A., Park, Brenden C., Kinch, Lisa, Pilch, Sylwia, Servage, Kelly A., Zhang, Junmei, Jiou, Jenny, Karasiewicz, Monika, Łobocka, Małgorzata, Grishin, Nick, Orth, Kim, Kucharczyk, Roza, Pawłowski, Krzysztof, Tomchick, Diana R., Tagliabracci, Vincent S.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524645/
https://ncbi.nlm.nih.gov/pubmed/30270044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.046
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