Protein AMPylation by an evolutionarily conserved pseudokinase

Approximately 10% of human protein kinases are believed to be inactive and named pseudokinases because they lack residues required for catalysis. Here we show that the highly conserved pseudokinase selenoprotein-O (SelO) transfers AMP from ATP to Ser, Thr and Tyr residues on protein substrates (AMPy...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell
Päätekijät: Sreelatha, Anju, Yee, Samantha S., Lopez, Victor A., Park, Brenden C., Kinch, Lisa, Pilch, Sylwia, Servage, Kelly A., Zhang, Junmei, Jiou, Jenny, Karasiewicz, Monika, Łobocka, Małgorzata, Grishin, Nick, Orth, Kim, Kucharczyk, Roza, Pawłowski, Krzysztof, Tomchick, Diana R., Tagliabracci, Vincent S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6524645/
https://ncbi.nlm.nih.gov/pubmed/30270044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.08.046
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