Inhibition of bacterial ubiquitin ligases by SidJ/Calmodulin-catalyzed glutamylation

The family of bacterial SidE enzymes catalyzes phosphoribosyl-linked (PR) serine ubiquitination and promotes infectivity of Legionella pneumophilia, a pathogenic bacterium causing Legionnaires’ disease(1,2,3). SidEs share the genetic locus with the Legionella effector SidJ that spatiotemporally oppo...

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Pubblicato in:Nature
Autori principali: Bhogaraju, Sagar, Bonn, Florian, Mukherjee, Rukmini, Adams, Michael, Pfleiderer, Moritz M., Galej, Wojciech P., Matkovic, Vigor, Lopez-Mosqueda, Jaime, Kalayil, Sissy, Shin, Donghyuk, Dikic, Ivan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715450/
https://ncbi.nlm.nih.gov/pubmed/31330532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1440-8
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