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Selectivity through discriminatory induced fit enables switching of NAD(P)H coenzyme specificity in Old Yellow Enzyme ene‐reductases

Most ene‐reductases belong to the Old Yellow Enzyme (OYE) family of flavin‐dependent oxidoreductases. OYEs use nicotinamide coenzymes as hydride donors to catalyze the reduction of alkenes that contain an electron‐withdrawing group. There have been many investigations of the structures and catalytic...

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Publicat a:FEBS J
Autors principals: Iorgu, Andreea I., Hedison, Tobias M., Hay, Sam, Scrutton, Nigel S.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6767020/
https://ncbi.nlm.nih.gov/pubmed/31033202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14862
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