Doxorubicin-induced cardiomyocyte death is mediated by unchecked mitochondrial fission and mitophagy

Doxorubicin (Dox) is a widely used antineoplastic agent that can cause heart failure. Dox cardiotoxicity is closely associated with mitochondrial damage. Mitochondrial fission and mitophagy are quality control mechanisms that normally help maintain a pool of healthy mitochondria. However, unchecked...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Catanzaro, Michael P., Weiner, Ashley, Kaminaris, Amanda, Li, Cairong, Cai, Fei, Zhao, Fengyi, Kobayashi, Satoru, Kobayashi, Tamayo, Huang, Yuan, Sesaki, Hiromi, Liang, Qiangrong
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766652/
https://ncbi.nlm.nih.gov/pubmed/31291545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802663R
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