Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans

Osteoporosis is a common skeletal disease, affecting millions of individuals worldwide. Currently used osteoporosis treatments substantially reduce vertebral fracture risk, whereas nonvertebral fracture risk, mainly caused by reduced cortical bone mass, has only moderately been improved by the osteo...

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Veröffentlicht in:FASEB J
Hauptverfasser: Movérare-Skrtic, Sofia, Nilsson, Karin H., Henning, Petra, Funck-Brentano, Thomas, Nethander, Maria, Rivadeneira, Fernando, Coletto Nunes, Glaucia, Koskela, Antti, Tuukkanen, Juha, Tuckermann, Jan, Perret, Christine, Souza, Pedro Paulo Chaves, Lerner, Ulf H., Ohlsson, Claes
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766646/
https://ncbi.nlm.nih.gov/pubmed/31307226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900707R
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