Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans

Osteoporosis is a common skeletal disease, affecting millions of individuals worldwide. Currently used osteoporosis treatments substantially reduce vertebral fracture risk, whereas nonvertebral fracture risk, mainly caused by reduced cortical bone mass, has only moderately been improved by the osteo...

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Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Movérare-Skrtic, Sofia, Nilsson, Karin H., Henning, Petra, Funck-Brentano, Thomas, Nethander, Maria, Rivadeneira, Fernando, Coletto Nunes, Glaucia, Koskela, Antti, Tuukkanen, Juha, Tuckermann, Jan, Perret, Christine, Souza, Pedro Paulo Chaves, Lerner, Ulf H., Ohlsson, Claes
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6766646/
https://ncbi.nlm.nih.gov/pubmed/31307226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201900707R
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