Expression of the Hutchinson-Gilford Progeria Mutation during Osteoblast Development Results in Loss of Osteocytes, Irregular Mineralization, and Poor Biomechanical Properties

Hutchinson-Gilford progeria syndrome (HGPS) is a very rare genetic disorder that is characterized by multiple features of premature aging and largely affects tissues of mesenchymal origin. In this study, we describe the development of a tissue-specific mouse model that overexpresses the most common...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Schmidt, Eva, Nilsson, Ola, Koskela, Antti, Tuukkanen, Juha, Ohlsson, Claes, Rozell, Björn, Eriksson, Maria
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460452/
https://ncbi.nlm.nih.gov/pubmed/22893709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366450
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker