Expression of the Hutchinson-Gilford Progeria Mutation during Osteoblast Development Results in Loss of Osteocytes, Irregular Mineralization, and Poor Biomechanical Properties

Hutchinson-Gilford progeria syndrome (HGPS) is a very rare genetic disorder that is characterized by multiple features of premature aging and largely affects tissues of mesenchymal origin. In this study, we describe the development of a tissue-specific mouse model that overexpresses the most common...

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Bibliografiska uppgifter
Huvudupphovsmän: Schmidt, Eva, Nilsson, Ola, Koskela, Antti, Tuukkanen, Juha, Ohlsson, Claes, Rozell, Björn, Eriksson, Maria
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2012
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460452/
https://ncbi.nlm.nih.gov/pubmed/22893709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366450
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