Ligand Conjugated Multimeric siRNAs Enable Enhanced Uptake and Multiplexed Gene Silencing

Small interfering RNAs (siRNAs) conjugated to N-acetylgalactosamine (GalNAc) ligands have been used to treat disease in patients. However, conjugates with other ligands deliver siRNA less efficiently, limiting the development of new targeted therapies. Most approaches to enhancing the potency of suc...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Brown, Jonathan M., Dahlman, James E., Neuman, Kristin K., Prata, Carla A.H., Krampert, Monika C., Hadwiger, Philipp M., Vornlocher, Hans-Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765208/
https://ncbi.nlm.nih.gov/pubmed/31393218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2019.0782
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados