Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

Gene silencing mediated by small interfering RNA (siRNA) is a novel approach in the development of new cancer therapeutics. Polycations used for nucleic acid delivery still remain heterogeneous compounds, despite continuous progress in polymer synthetic technologies. Here we report the development o...

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Bibliographic Details
Main Authors: Dohmen, Christian, Fröhlich, Thomas, Lächelt, Ulrich, Röhl, Ingo, Vornlocher, Hans-Peter, Hadwiger, Philipp, Wagner, Ernst
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381594/
https://ncbi.nlm.nih.gov/pubmed/23344624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2011.10
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