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Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

Gene silencing mediated by small interfering RNA (siRNA) is a novel approach in the development of new cancer therapeutics. Polycations used for nucleic acid delivery still remain heterogeneous compounds, despite continuous progress in polymer synthetic technologies. Here we report the development o...

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Detalhes bibliográficos
Main Authors: Dohmen, Christian, Fröhlich, Thomas, Lächelt, Ulrich, Röhl, Ingo, Vornlocher, Hans-Peter, Hadwiger, Philipp, Wagner, Ernst
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381594/
https://ncbi.nlm.nih.gov/pubmed/23344624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2011.10
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