Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing

Gene silencing mediated by small interfering RNA (siRNA) is a novel approach in the development of new cancer therapeutics. Polycations used for nucleic acid delivery still remain heterogeneous compounds, despite continuous progress in polymer synthetic technologies. Here we report the development o...

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Hlavní autoři: Dohmen, Christian, Fröhlich, Thomas, Lächelt, Ulrich, Röhl, Ingo, Vornlocher, Hans-Peter, Hadwiger, Philipp, Wagner, Ernst
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381594/
https://ncbi.nlm.nih.gov/pubmed/23344624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2011.10
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