Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours

We studied a new amyloid-beta precursor protein (App) knock-in mouse model of Alzheimer's disease (App(NL-G-F)), containing the Swedish KM670/671NL mutation, the Iberian I716F mutation and the Artic E693G mutation, which generates elevated levels of amyloid beta (Aβ)(40) and Aβ(42) without the...

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Vydáno v:Dis Model Mech
Hlavní autoři: Pervolaraki, Eleftheria, Hall, Stephen P., Foresteire, Denise, Saito, Takashi, Saido, Takaomi C., Whittington, Miles A., Lever, Colin, Dachtler, James
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765200/
https://ncbi.nlm.nih.gov/pubmed/31439589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.040550
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