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Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

BACKGROUND: Alzheimer’s disease (AD), the most common cause of dementia, is characterized by the progressive deposition of amyloid-β (Aβ) peptides and neurofibrillary tangles. Mouse models of Aβ amyloidosis generated by knock-in (KI) of a humanized Aβ sequence provide distinct advantages over tradit...

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Bibliografiske detaljer
Udgivet i:BMC Neurosci
Main Authors: Sakakibara, Yasufumi, Sekiya, Michiko, Saito, Takashi, Saido, Takaomi C., Iijima, Koichi M.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6064053/
https://ncbi.nlm.nih.gov/pubmed/30055565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12868-018-0446-8
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