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Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old App(NL/NL) Knock-In Mice
Commonly used Alzheimer’s disease mouse models are based on the ectopic overexpression of the human amyloid precursor protein (APP) gene, together with a mutant presenilin gene. Surprisingly, humanized APP knock-in mouse models carrying a single APP Swedish mutation (App(NL)), failed to develop amyl...
Kaydedildi:
| Yayımlandı: | J Alzheimers Dis |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
IOS Press
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6218137/ https://ncbi.nlm.nih.gov/pubmed/30320577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-180410 |
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