Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old App(NL/NL) Knock-In Mice

Commonly used Alzheimer’s disease mouse models are based on the ectopic overexpression of the human amyloid precursor protein (APP) gene, together with a mutant presenilin gene. Surprisingly, humanized APP knock-in mouse models carrying a single APP Swedish mutation (App(NL)), failed to develop amyl...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Alzheimers Dis
Auteurs principaux: Salas, Isabel H., Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Saido, Takaomi C., Dotti, Carlos G., De Strooper, Bart
Format: Artigo
Langue:Inglês
Publié: IOS Press 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218137/
https://ncbi.nlm.nih.gov/pubmed/30320577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-180410
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires