Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP(NL-F/NL-F) knock-in mice

Amyloid pathology occurs early in Alzheimer’s disease (AD), and has therefore been the focus of numerous studies. Transgenic mouse models have been instrumental to study amyloidosis, but observations might have been confounded by APP-overexpression artifacts. The current study investigated early fun...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Shah, Disha, Latif-Hernandez, Amira, De Strooper, Bart, Saito, Takashi, Saido, Takaomi, Verhoye, Marleen, D’Hooge, Rudi, Van der Linden, Annemie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908850/
https://ncbi.nlm.nih.gov/pubmed/29674739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24657-9
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