Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes

Insulin and IGF-1 actions in vascular smooth muscle cells (VSMC) are associated with accelerated arterial intima hyperplasia and restenosis after angioplasty, especially in diabetes. To distinguish their relative roles, we delete insulin receptor (SMIRKO) or IGF-1 receptor (SMIGF1RKO) in VSMC and in...

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書誌詳細
出版年:Nat Commun
主要な著者: Li, Qian, Fu, Jialin, Xia, Yu, Qi, Weier, Ishikado, Atsushi, Park, Kyoungmin, Yokomizo, Hisashi, Huang, Qian, Cai, Weikang, Rask-Madsen, Christian, Kahn, C. Ronald, King, George L.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2019
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765023/
https://ncbi.nlm.nih.gov/pubmed/31562314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12368-2
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