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Induction of Vascular Insulin Resistance, Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C β Isoform in the Endothelium

RATIONALE: Loss of insulin action on the endothelium can cause endothelial dysfunction and atherosclerosis. Hyperglycemia and elevated fatty acids induced by diabetes can activate protein kinase C (PKC) β isoforms and selectively inhibit insulin signaling via phosphatidylinositol 3-kinase (PI3K)/Akt...

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Detalhes bibliográficos
Main Authors: Li, Qian, Park, Kyoungmin, Li, Chenzhong, Rask-Madsen, Christian, Mima, Akira, Qi, Weier, Huang, Koji MizutaniPaul, King, George L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893704/
https://ncbi.nlm.nih.gov/pubmed/23759514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.301074
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