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Induction of Vascular Insulin Resistance, Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C β Isoform in the Endothelium
RATIONALE: Loss of insulin action on the endothelium can cause endothelial dysfunction and atherosclerosis. Hyperglycemia and elevated fatty acids induced by diabetes can activate protein kinase C (PKC) β isoforms and selectively inhibit insulin signaling via phosphatidylinositol 3-kinase (PI3K)/Akt...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3893704/ https://ncbi.nlm.nih.gov/pubmed/23759514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.301074 |
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