Homozygous receptors for insulin and not IGF-1 accelerate intimal hyperplasia in insulin resistance and diabetes

Insulin and IGF-1 actions in vascular smooth muscle cells (VSMC) are associated with accelerated arterial intima hyperplasia and restenosis after angioplasty, especially in diabetes. To distinguish their relative roles, we delete insulin receptor (SMIRKO) or IGF-1 receptor (SMIGF1RKO) in VSMC and in...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Li, Qian, Fu, Jialin, Xia, Yu, Qi, Weier, Ishikado, Atsushi, Park, Kyoungmin, Yokomizo, Hisashi, Huang, Qian, Cai, Weikang, Rask-Madsen, Christian, Kahn, C. Ronald, King, George L.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765023/
https://ncbi.nlm.nih.gov/pubmed/31562314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12368-2
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