Inhibition of EZH2 ameliorates lupus-like disease in MRL/lpr mice

OBJECTIVES: We previously revealed a role for EZH2 in inducing pro-inflammatory epigenetic changes in lupus CD4+ T cells. In this study, we sought to determine if inhibiting EZH2 ameliorates lupus-like disease in MRL/lpr mice. METHODS: EZH2 expression levels in multiple cell types in lupus patients...

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Bibliografiske detaljer
Udgivet i:Arthritis Rheumatol
Main Authors: Rohraff, Dallas M., He, Ye, Farkash, Evan A., Schonfeld, Mark, Tsou, Pei-Suen, Sawalha, Amr H.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6764871/
https://ncbi.nlm.nih.gov/pubmed/31106974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40931
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