Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness

Differentiated cancer cells reacquiring stem cell traits following radiotherapy may enrich cancer stem cells and accelerate tumor recurrence and metastasis. We are interested in the mechanistic role of dying cells-derived HMGB1 in CD133(−) pancreatic cancer cells dedifferentiation following radiothe...

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Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Zhang, Lirong, Shi, Hui, Chen, Hongbo, Gong, Aihua, Liu, Yanfang, Song, Lian, Xu, Xuewen, You, Tao, Fan, Xin, Wang, Dongqing, Cheng, Fang, Zhu, Haitao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763460/
https://ncbi.nlm.nih.gov/pubmed/31558702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1956-8
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