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Dedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness

Differentiated cancer cells reacquiring stem cell traits following radiotherapy may enrich cancer stem cells and accelerate tumor recurrence and metastasis. We are interested in the mechanistic role of dying cells-derived HMGB1 in CD133(−) pancreatic cancer cells dedifferentiation following radiothe...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Lirong, Shi, Hui, Chen, Hongbo, Gong, Aihua, Liu, Yanfang, Song, Lian, Xu, Xuewen, You, Tao, Fan, Xin, Wang, Dongqing, Cheng, Fang, Zhu, Haitao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763460/
https://ncbi.nlm.nih.gov/pubmed/31558702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1956-8
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