Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma

Despite progress in intensification of therapy, outcomes for patients with metastatic osteosarcoma (OS) have not improved in thirty years. We developed a system that enabled preclinical screening of compounds against metastatic OS cells in the context of the native lung microenvironment. Using this...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bayles, Ian, Krajewska, Malgorzata, Pontius, W. Dean, Saiakhova, Alina, Morrow, James J., Bartels, Cynthia, Lu, Jim, Faber, Zachary J., Fedorov, Yuriy, Hong, Ellen S., Karnuta, Jaret M., Rubin, Brian, Adams, Drew J., George, Rani E., Scacheri, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763270/
https://ncbi.nlm.nih.gov/pubmed/31498151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127718
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