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Positively selected enhancer elements endow osteosarcoma cells with metastatic competence
Metastasis results from a complex set of traits acquired by tumor cells, distinct from those necessary for tumorigenesis. Here, we investigate the contribution of enhancer elements to the metastatic phenotype of osteosarcoma. Through epigenomic profiling, we identify substantial differences in enhan...
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| Publicado no: | Nat Med |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5803371/ https://ncbi.nlm.nih.gov/pubmed/29334376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4475 |
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