Positively selected enhancer elements endow osteosarcoma cells with metastatic competence

Metastasis results from a complex set of traits acquired by tumor cells, distinct from those necessary for tumorigenesis. Here, we investigate the contribution of enhancer elements to the metastatic phenotype of osteosarcoma. Through epigenomic profiling, we identify substantial differences in enhan...

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Publicat a:Nat Med
Autors principals: Morrow, James J., Bayles, Ian, Funnell, Alister PW, Miller, Tyler E., Saiakhova, Alina, Lizardo, Michael M., Bartels, Cynthia F., Kapteijn, Maaike Y., Hung, Stevephen, Mendoza, Arnulfo, Dhillon, Gursimran, Chee, Daniel R., Myers, Jay T., Allen, Frederick, Gambarotti, Marco, Righi, Alberto, DiFeo, Analisa, Rubin, Brian P., Huang, Alex Y., Meltzer, Paul S., Helman, Lee J., Picci, Piero, Versteeg, Henri, Stamatoyannopolus, John, Khanna, Chand, Scacheri, Peter C.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803371/
https://ncbi.nlm.nih.gov/pubmed/29334376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4475
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