Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with diverse drivers of disease progression and mechanisms of therapeutic resistance. We conducted deep phenotypic characterization of CRPC metastases and patient-derived xenograft (PDX) lines using whole-genome RNA s...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Labrecque, Mark P., Coleman, Ilsa M., Brown, Lisha G., True, Lawrence D., Kollath, Lori, Lakely, Bryce, Nguyen, Holly M., Yang, Yu C., da Costa, Rui M. Gil, Kaipainen, Arja, Coleman, Roger, Higano, Celestia S., Yu, Evan Y., Cheng, Heather H., Mostaghel, Elahe A., Montgomery, Bruce, Schweizer, Michael T., Hsieh, Andrew C., Lin, Daniel W., Corey, Eva, Nelson, Peter S., Morrissey, Colm
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763249/
https://ncbi.nlm.nih.gov/pubmed/31361600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128212
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