SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer

PURPOSE: The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. EXPERIMENTAL DESIGN: Expression of chromogranin A (CHGA), synaptophysin (SYP)...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Zhang, Xiaotun, Coleman, Ilsa M., Brown, Lisha G., True, Lawrence D., Kollath, Lori, Lucas, Jared M., Lam, Hung-Ming, Dumpit, Ruth, Corey, Eva, Chéry, Lisly, Lakely, Bryce, Higano, Celestia S., Montgomery, Bruce, Roudier, Martine, Lange, Paul H., Nelson, Peter S., Vessella, Robert L., Morrissey, Colm
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609255/
https://ncbi.nlm.nih.gov/pubmed/26071481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-0157
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