Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with diverse drivers of disease progression and mechanisms of therapeutic resistance. We conducted deep phenotypic characterization of CRPC metastases and patient-derived xenograft (PDX) lines using whole-genome RNA s...

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Pubblicato in:J Clin Invest
Autori principali: Labrecque, Mark P., Coleman, Ilsa M., Brown, Lisha G., True, Lawrence D., Kollath, Lori, Lakely, Bryce, Nguyen, Holly M., Yang, Yu C., da Costa, Rui M. Gil, Kaipainen, Arja, Coleman, Roger, Higano, Celestia S., Yu, Evan Y., Cheng, Heather H., Mostaghel, Elahe A., Montgomery, Bruce, Schweizer, Michael T., Hsieh, Andrew C., Lin, Daniel W., Corey, Eva, Nelson, Peter S., Morrissey, Colm
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763249/
https://ncbi.nlm.nih.gov/pubmed/31361600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128212
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