Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer

Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with diverse drivers of disease progression and mechanisms of therapeutic resistance. We conducted deep phenotypic characterization of CRPC metastases and patient-derived xenograft (PDX) lines using whole-genome RNA s...

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Vydáno v:J Clin Invest
Hlavní autoři: Labrecque, Mark P., Coleman, Ilsa M., Brown, Lisha G., True, Lawrence D., Kollath, Lori, Lakely, Bryce, Nguyen, Holly M., Yang, Yu C., da Costa, Rui M. Gil, Kaipainen, Arja, Coleman, Roger, Higano, Celestia S., Yu, Evan Y., Cheng, Heather H., Mostaghel, Elahe A., Montgomery, Bruce, Schweizer, Michael T., Hsieh, Andrew C., Lin, Daniel W., Corey, Eva, Nelson, Peter S., Morrissey, Colm
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763249/
https://ncbi.nlm.nih.gov/pubmed/31361600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128212
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