The Acute Antihyperalgesic Action of Nonsteroidal, Anti-Inflammatory Drugs and Release of Spinal Prostaglandin E(2) Is Mediated by the Inhibition of Constitutive Spinal Cyclooxygenase-2 (COX-2) but not COX-1

Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal and ventral horns and in the dorsal root ganglia. Using selective inhibitors of cyclooxygenase (COX) isozymes, we show that in rats with chronic indwelling intrathecal catheters the acute thermal hyperalgesia...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Yaksh, Tony L., Dirig, David M., Conway, Charles M., Svensson, Camilla, Luo, Z. David, Isakson, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763183/
https://ncbi.nlm.nih.gov/pubmed/11487607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-16-05847.2001
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