The Acute Antihyperalgesic Action of Nonsteroidal, Anti-Inflammatory Drugs and Release of Spinal Prostaglandin E(2) Is Mediated by the Inhibition of Constitutive Spinal Cyclooxygenase-2 (COX-2) but not COX-1

Western blots show the constitutive expression of COX-1 and COX-2 in the rat spinal dorsal and ventral horns and in the dorsal root ganglia. Using selective inhibitors of cyclooxygenase (COX) isozymes, we show that in rats with chronic indwelling intrathecal catheters the acute thermal hyperalgesia...

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Xehetasun bibliografikoak
Argitaratua izan da:J Neurosci
Egile Nagusiak: Yaksh, Tony L., Dirig, David M., Conway, Charles M., Svensson, Camilla, Luo, Z. David, Isakson, Peter C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2001
Gaiak:
ARTICLE
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763183/
https://ncbi.nlm.nih.gov/pubmed/11487607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-16-05847.2001
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