α-1-Antichymotrypsin Promotes β-Sheet Amyloid Plaque Deposition in a Transgenic Mouse Model of Alzheimer's Disease

α(1)-Antichymotrypsin (ACT), an acute-phase inflammatory protein, is an integral component of the amyloid deposits in Alzheimer's disease (AD) and has been shown to catalyze amyloid β-peptide polymerization in vitro. We have investigated the impact of ACT on amyloid deposition in vivo by genera...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Nilsson, Lars N. G., Bales, Kelly R., DiCarlo, Giovanni, Gordon, Marcia N., Morgan, Dave, Paul, Steven M., Potter, Huntington
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762932/
https://ncbi.nlm.nih.gov/pubmed/11222634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-05-01444.2001
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