Activation of Synaptic NMDA Receptors by Action Potential-Dependent Release of Transmitter during Hypoxia Impairs Recovery of Synaptic Transmission on Reoxygenation

Increased levels of glutamate and the subsequent activation of NMDA receptors are responsible for neuronal damage that occurs after an ischemic or hypoxic episode. In the present work, we investigated the relative contribution of presynaptic and postsynaptic blockade of synaptic transmission, as wel...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Sebastião, Ana M., de Mendonça, Alexandre, Moreira, Tiago, Ribeiro, J. Alexandre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2001
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762820/
https://ncbi.nlm.nih.gov/pubmed/11606644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-21-08564.2001
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