Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Parkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are caused by a heterogeneous d...

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Publicat a:J Neurosci
Autors principals: Diógenes, Maria José, Dias, Raquel B., Rombo, Diogo M., Vicente Miranda, Hugo, Maiolino, Francesca, Guerreiro, Patrícia, Näsström, Thomas, Franquelim, Henri G., Oliveira, Luís M.A., Castanho, Miguel A.R.B., Lannfelt, Lars, Bergström, Joakim, Ingelsson, Martin, Quintas, Alexandre, Sebastião, Ana M., Lopes, Luísa V., Outeiro, Tiago Fleming
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703775/
https://ncbi.nlm.nih.gov/pubmed/22915117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0234-12.2012
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