Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

Parkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are caused by a heterogeneous d...

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Vydáno v:J Neurosci
Hlavní autoři: Diógenes, Maria José, Dias, Raquel B., Rombo, Diogo M., Vicente Miranda, Hugo, Maiolino, Francesca, Guerreiro, Patrícia, Näsström, Thomas, Franquelim, Henri G., Oliveira, Luís M.A., Castanho, Miguel A.R.B., Lannfelt, Lars, Bergström, Joakim, Ingelsson, Martin, Quintas, Alexandre, Sebastião, Ana M., Lopes, Luísa V., Outeiro, Tiago Fleming
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703775/
https://ncbi.nlm.nih.gov/pubmed/22915117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0234-12.2012
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