Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes

BACKGROUND: Due to its neurotoxic properties, oligomeric alpha-synuclein (α-syn) has been suggested as an attractive target for passive immunization against Parkinson’s disease (PD). In mouse models of PD, antibody treatment has been shown to lower the levels of pathogenic α-syn species, including o...

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Pubblicato in:J Neuroinflammation
Autori principali: Gustafsson, Gabriel, Lindström, Veronica, Rostami, Jinar, Nordström, Eva, Lannfelt, Lars, Bergström, Joakim, Ingelsson, Martin, Erlandsson, Anna
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5725978/
https://ncbi.nlm.nih.gov/pubmed/29228971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-1018-z
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