Crosstalk between astrocytes and microglia results in increased degradation of α-synuclein and amyloid-β aggregates

BACKGROUND: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by brain accumulation of aggregated amyloid-beta (Aβ) and alpha-synuclein (αSYN), respectively. In order to develop effective therapies, it is crucial to understand how the Aβ/αSYN aggregates can be cleared. Compelli...

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Udgivet i:J Neuroinflammation
Main Authors: Rostami, Jinar, Mothes, Tobias, Kolahdouzan, Mahshad, Eriksson, Olle, Moslem, Mohsen, Bergström, Joakim, Ingelsson, Martin, O’Callaghan, Paul, Healy, Luke M., Falk, Anna, Erlandsson, Anna
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8173980/
https://ncbi.nlm.nih.gov/pubmed/34082772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02158-3
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